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Oral cavity: An open horizon for nanopharmaceuticals

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Main Author: Oanh Oanh Thi Nguyen
Other Authors: Khue Dan Tran
Format: Article
Language:English
Published: Journal of Pharmaceutical Investigation 2021
Subjects:
Oral cavity
Nanoparticles
Bioavailability
Dentistry
Online Access:https://link.springer.com/article/10.1007/s40005-021-00530-2
https://dlib.phenikaa-uni.edu.vn/handle/PNK/1958
https://doi.org/10.1007/s40005-021-00530-2
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spelling oai:localhost:PNK-19582022-08-17T05:54:53Z Oral cavity: An open horizon for nanopharmaceuticals Oanh Oanh Thi Nguyen Khue Dan Tran Nhan Thi Ha Sang Minh Doan Thi Thanh Hai Dinh Tuan Hiep Tran Oral cavity Nanoparticles Bioavailability Dentistry Q1 Background Oral administration is the primary route employed for drug delivery. In addition to the gastrointestinal tract, the oral cavity has been drawing considerable attention owing to its physiological properties and advances in drug carrier development. Notably, nanotechnology has made immense contributions to enhancing drug bioavailability, stability, and efficacy, both in research and clinical settings. Area covered The present review comprises lessons from physiological characteristics to fundamental material science knowledge, summarizing the pros and cons of nanotechnology applications in therapeutic drug delivery. The oral cavity presents inherent challenges, including oral cancer, dental caries, oral infection, or oral inflammation, that necessitate local solutions. Simultaneously, the vascular system under the tongue and in the buccal region offers a portal for systemic drug absorption. Expert opinion Among available delivery systems, nanoparticle-based drug delivery, with the oral cavity as the action or absorption site, can be developed as a principal dosage formulation. Although convenience and fast onset might be advantageous, additional studies are warranted for preclinical characterization, especially in animal models, and for determining manufacturing competence, prior to human trials to meet standards in clinical settings. 2021-07-06T03:10:55Z 2021-07-06T03:10:55Z 2021 Article https://link.springer.com/article/10.1007/s40005-021-00530-2 https://dlib.phenikaa-uni.edu.vn/handle/PNK/1958 https://doi.org/10.1007/s40005-021-00530-2 en application/pdf Journal of Pharmaceutical Investigation
institution Digital Phenikaa
collection Digital Phenikaa
language English
topic Oral cavity
Nanoparticles
Bioavailability
Dentistry
spellingShingle Oral cavity
Nanoparticles
Bioavailability
Dentistry
Oanh Oanh Thi Nguyen
Oral cavity: An open horizon for nanopharmaceuticals
description Q1
author2 Khue Dan Tran
author_facet Khue Dan Tran
Oanh Oanh Thi Nguyen
format Article
author Oanh Oanh Thi Nguyen
author_sort Oanh Oanh Thi Nguyen
title Oral cavity: An open horizon for nanopharmaceuticals
title_short Oral cavity: An open horizon for nanopharmaceuticals
title_full Oral cavity: An open horizon for nanopharmaceuticals
title_fullStr Oral cavity: An open horizon for nanopharmaceuticals
title_full_unstemmed Oral cavity: An open horizon for nanopharmaceuticals
title_sort oral cavity: an open horizon for nanopharmaceuticals
publisher Journal of Pharmaceutical Investigation
publishDate 2021
url https://link.springer.com/article/10.1007/s40005-021-00530-2
https://dlib.phenikaa-uni.edu.vn/handle/PNK/1958
https://doi.org/10.1007/s40005-021-00530-2
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score 8.891787

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