Mitochondria-targeting multi-metallic ZnCuO nanoparticles and IR780 for efficient photodynamic and photothermal cancer treatments
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| Định dạng: | Bài Báo |
| Ngôn ngữ: | English |
| Nhà xuất bản: |
Journal of Materials Science & Technology
2021
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| Truy cập trực tuyến: | https://www.sciencedirect.com/science/article/abs/pii/S1005030221001730?via%3Dihub#! https://dlib.phenikaa-uni.edu.vn/handle/PNK/1956 https://doi.org/10.1016/j.jmst.2021.01.035 |
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oai:localhost:PNK-19562022-08-17T05:54:53Z Mitochondria-targeting multi-metallic ZnCuO nanoparticles and IR780 for efficient photodynamic and photothermal cancer treatments Hima Bindu Ruttala Thiruganesh Ramasamy Raghu Ram Teja Ruttala Tuan Hiep Tran Jee-Heon Jeong Han-Gon Choi Sae Kwang Ku Chul Soon Yong Jong Oh Kim Zinc-doped copper Nanoparticles Mitochondria Cancer Q1 Chemo-resistance has pushed cancer treatment to the boundary of failure. This challenge has encouraged scientists to look for nanotechnological solutions. In this study, we have taken this goal one step further without depending on chemotherapy. Specifically, hybrid metal, polymer, and lipid nanoparticles that formed an IR780-a photosensitizer and Zinc copper oxide incorporated nanoparticle (ZCNP) nanoparticles were utilized in a combined photothermal and photodynamic therapy. Through the mediation of triphenylphosphonium (TPP) as a mitochondria-targeting moiety, TPP-conjugated polymer-lipid hybrid nanoparticles containing ZCNP/IR-780 significantly enhanced cellular uptake by cancer cells and selectively targeted the mitochondria, which improved the induction of apoptosis. In tumor-bearing mice, the nanoparticles were detected predominantly in tumors rather than in the other principle organs, which did not show notable signs of toxicity. Both in vitro and in vivo results demonstrated a great improvement in photothermal and photodynamic efficacy in combination when compared to either one individually, and a significant inhibition of tumor growth was observed with the combined therapies. In summary, this study describes an effective mitochondria-targeting nanocarrier for the treatment of cancer using combined photothermal and photodynamic therapies. 2021-07-06T03:06:56Z 2021-07-06T03:06:56Z 2021 Article https://www.sciencedirect.com/science/article/abs/pii/S1005030221001730?via%3Dihub#! https://dlib.phenikaa-uni.edu.vn/handle/PNK/1956 https://doi.org/10.1016/j.jmst.2021.01.035 en application/pdf Journal of Materials Science & Technology |
| institution |
Digital Phenikaa |
| collection |
Digital Phenikaa |
| language |
English |
| topic |
Zinc-doped copper Nanoparticles Mitochondria Cancer |
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Zinc-doped copper Nanoparticles Mitochondria Cancer Hima Bindu Ruttala Mitochondria-targeting multi-metallic ZnCuO nanoparticles and IR780 for efficient photodynamic and photothermal cancer treatments |
| description |
Q1 |
| author2 |
Thiruganesh Ramasamy |
| author_facet |
Thiruganesh Ramasamy Hima Bindu Ruttala |
| format |
Article |
| author |
Hima Bindu Ruttala |
| author_sort |
Hima Bindu Ruttala |
| title |
Mitochondria-targeting multi-metallic ZnCuO nanoparticles and IR780 for efficient photodynamic and photothermal cancer treatments |
| title_short |
Mitochondria-targeting multi-metallic ZnCuO nanoparticles and IR780 for efficient photodynamic and photothermal cancer treatments |
| title_full |
Mitochondria-targeting multi-metallic ZnCuO nanoparticles and IR780 for efficient photodynamic and photothermal cancer treatments |
| title_fullStr |
Mitochondria-targeting multi-metallic ZnCuO nanoparticles and IR780 for efficient photodynamic and photothermal cancer treatments |
| title_full_unstemmed |
Mitochondria-targeting multi-metallic ZnCuO nanoparticles and IR780 for efficient photodynamic and photothermal cancer treatments |
| title_sort |
mitochondria-targeting multi-metallic zncuo nanoparticles and ir780 for efficient photodynamic and photothermal cancer treatments |
| publisher |
Journal of Materials Science & Technology |
| publishDate |
2021 |
| url |
https://www.sciencedirect.com/science/article/abs/pii/S1005030221001730?via%3Dihub#! https://dlib.phenikaa-uni.edu.vn/handle/PNK/1956 https://doi.org/10.1016/j.jmst.2021.01.035 |
| _version_ |
1751856256398655488 |
| score |
8.891145 |