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Emerging roles of non‑coding RNAs in the response of rectal cancer to radiotherapy

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Main Author: Ha Thi, Huyen Trang
Other Authors: Duong, Hong‑Quan
Format: Article
Language:English
Published: International Journal of Oncology 2021
Online Access:https://www.spandidos-publications.com/10.3892/ijo.2021.5175
https://dlib.phenikaa-uni.edu.vn/handle/PNK/1768
https://doi.org/10.3892/ijo.2021.5175
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spelling oai:localhost:PNK-17682022-08-17T05:54:42Z Emerging roles of non‑coding RNAs in the response of rectal cancer to radiotherapy Ha Thi, Huyen Trang Duong, Hong‑Quan Hong, Suntaek Q2 Radiotherapy (RT) followed by radical surgery is an effective standard treatment strategy for various types of cancer, including rectal cancer. The response to RT varies among patients, and the radiosensitivity of cancer cells determines the clinical outcome of patients. However, the application of RT to patients with radioresistant tumors may result in radiation‑induced toxicity without clinical benefits. Currently, there are no effective methods to predict the response to RT. The limitations of the methods currently used to evaluate tumor radiosensitivity, which are mainly based on clinical and radiological features, are low sensitivity and specificity. Non‑coding RNAs (ncRNAs) have emerged as a class of biomarkers for predicting radiosensitivity. In particular, the expression pattern of ncRNAs can predict the response to RT in patients with rectal cancer. Thus, ncRNAs may be used as potential biomarkers and therapeutic targets to improve the diagnosis and treatment outcome of patients with rectal cancer. In the present review, the current knowledge on the limitations of RT for rectal cancer and the association between ncRNA expression and sensitivity of rectal cancer to RT are presented. Additionally, the potential of ncRNAs as predictive biomarkers and therapeutic targets to mitigate resistance of rectal cancer to RT is discussed. 2021-06-15T04:02:04Z 2021-06-15T04:02:04Z 2021 Article Working Paper https://www.spandidos-publications.com/10.3892/ijo.2021.5175 https://dlib.phenikaa-uni.edu.vn/handle/PNK/1768 https://doi.org/10.3892/ijo.2021.5175 en International Journal of Oncology
institution Digital Phenikaa
collection Digital Phenikaa
language English
description Q2
author2 Duong, Hong‑Quan
author_facet Duong, Hong‑Quan
Ha Thi, Huyen Trang
format Article
author Ha Thi, Huyen Trang
spellingShingle Ha Thi, Huyen Trang
Emerging roles of non‑coding RNAs in the response of rectal cancer to radiotherapy
author_sort Ha Thi, Huyen Trang
title Emerging roles of non‑coding RNAs in the response of rectal cancer to radiotherapy
title_short Emerging roles of non‑coding RNAs in the response of rectal cancer to radiotherapy
title_full Emerging roles of non‑coding RNAs in the response of rectal cancer to radiotherapy
title_fullStr Emerging roles of non‑coding RNAs in the response of rectal cancer to radiotherapy
title_full_unstemmed Emerging roles of non‑coding RNAs in the response of rectal cancer to radiotherapy
title_sort emerging roles of non‑coding rnas in the response of rectal cancer to radiotherapy
publisher International Journal of Oncology
publishDate 2021
url https://www.spandidos-publications.com/10.3892/ijo.2021.5175
https://dlib.phenikaa-uni.edu.vn/handle/PNK/1768
https://doi.org/10.3892/ijo.2021.5175
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score 8.891145

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